Sigmoidoscopy Screening Probably Works, but How Well Is Still Unknown
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چکیده
منابع مشابه
Sigmoidoscopy screening probably works, but how well is still unknown.
The most persuasive scientific evidence for the benefit of a cancer screening test comes from a randomized controlled clinical trial (RCT) where the endpoint is a reduction in mortality from (or incidence of) the disease of interest. There have been three RCTs of a fecal occult blood test (Hemoccult; Beckman Coulter, Palo Alto, CA) for early detection of colorectal cancer involving more than 25...
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in distribution volume may lead to decreased plasma exposure. Additionally, an increase in glomerular filtration could likely lead to increased excretion. Moreover, amniotic fluid may act as a third space for many drugs, as recently documented for dasatinib [5] . Finally, the decrease in albumin level observed during pregnancy may favor the transplacental transfer rate of many drugs, especially...
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www.thelancet.com Published online February 21, 2017 http://dx.doi.org/10.1016/S0140-6736(17)30542-1 1 Worldwide, colorectal cancer is the third most common incident cancer and the fourth leading cause of cancer death, with 1·4 million new cases and 700 000 deaths estimated in 2012—most of these from the developed world. Over the past three decades, several methods to screen for colorectal canc...
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DESCRIPTION A 46-year-old man was transferred from an outside hospital for evaluation of acute renal failure and non-ST-segment elevation myocardial infarction. During his initial presentation at the outside hospital, the patient was profoundly hypotensive with signs of respiratory failure. Owing to the perceived urgency, he was started on norepinephrine for haemodynamic support through a perip...
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In a recent meta-analysis, Roberts and coworkers have raised several concerns about the safety profile of paracetamol. The criticism was supported by a clear association between exposure and risk of major end points (all-cause mortality, cardiovascular disease (CVD), hypertension, gastrointestinal (GI) disorders, renal failure) and a clear demonstration of a dose–response effect. Although Rober...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2003
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/95.8.571